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| Anti-HIV Nucleosides: Past, Present and Future (Medical Intelligence Unit) |  | Creator: Hiroaki Mitsuya
Publisher: Springer
Category: Book
Buy New: $67.64
as of 7/29/2010 06:10 CDT details
Seller: Amazon.com
Media: Hardcover
Edition: 1
Pages: 178
Number Of Items: 1
ISBN: 354061950X
EAN: 9783540619505
ASIN: 354061950X
Publication Date: May 15, 1997
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Product Description
In 1985, a broad family of dideoxynucleoside reverse transcriptase inhibitors were identified as being active against a divergent range of HIV in vitro. Three such drugs - AZT, ddC, and ddI - had become prescription drugs by 1991. More recently, d4T and 3TC have been added to this nucleoside armamentarium. Indeed, despite their side effects, insufficient antiviral activity, and the propensity of HIV-1 to develop drug resistance, anti-HIV nucleosides have brought about substantial clinical benefits to HIV-1-infected individuals in the last decade. Even with the development of new modalities of AIDS therapy, anti-HIV nucleosides will continue to play a major role in the therapy of HIV-1 infection. This book discusses the development, rationale, present status, and the future of the use of anti-HIV nucleosides.
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